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Odds of use

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BLUE boxesstandard therapies
PINK boxesclinical trials

Odds of a child having a condition treated by their own (autologous) Cord Blood Stem Cells

OddsIndication
1 in 5,000 in USAStem Cell Transplant by age 20
1 in 44 (2.3%) kids age 8 in USAAutism Spectrum Disorder (ASD) Prevalence
1 in 300 (0.3%) all kids ages 5-10 in USACerebral Palsy (CP) Prevalence
2 per 1000 (0.2%) babies at full-term birth worldwideCerebral Palsy (CP) Incidence full-term
2.2 per 100 (2.2%) babies at premature birth worldwideCerebral Palsy (CP) Incidence premies
2 per 1000 birthsHypoxic Ischemic Encephalopathy (HIE)
#1 cause childhood death in USA: 435,000 per year ages 0-14Traumatic Brain Injury
6.2 per 1000 at birthmajor Congenital Heart Defects

Table researched by Frances Verter, PhD ©2014-2022; References Below

Odds of a child having a condition treated by donor (allogeneic, includes siblings) Cord Blood Stem Cells

OddsIndication
1 in 2,500 in USAStem Cell Transplant by age 20
10,000 babies per year in IndiaThalassemia Major births in India, up to 30% of the
population carries some form of Thalassemia Trait
1 in 44 (2.3%) kids age 8 in USAAutism Spectrum Disorder (ASD) Prevalence
1 in 300 (0.3%) all kids ages 5-10 in USACerebral Palsy (CP) Prevalence
2 per 1000 (0.2%) babies at full-term birth worldwideCerebral Palsy (CP) Incidence full-term
2.2 per 100 (2.2%) babies at premature birth worldwideCerebral Palsy (CP) Incidence premies
1 in 4 (25%) premies under 1500gmPremature Lungs (BronchoPulmonary Dysplasia)
1 in 10 adolescentsKnee Cartilage Tear Incidence
691,650 people per year in USAIschemic Stroke Incidence

Table researched by Frances Verter, PhD ©2014-2022; References Below

References

  • Apraxia publication autologous cord blood therapy: McLaughlin CA, Fitzgerald RA, Allison J, Waters-Pick B, Sun J, Kurtzberg J. Treatment of Childhood Apraxia with Autologous Cord Blood Infusions. BBMT 2017; 23(3):S149. doi:10.1016/j.bbmt.2016.12.289
  • Autism: Statistic 1 in 44 children have autism spectrum disorders is prevalence from CDC.
  • Autism publication using both autologous and matched allogeneic cord blood: Dawson G, Sun JM, Baker J, ... Waters-Pick B, Troy J, Kurtzberg J. A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder. Pediatrics 2020; 222:164-173. doi:10.1016/j.jpeds.2020.03.011
  • Autism review: Kurtzberg J. Results from the Duke ACT Study of Cord Blood for Autism: Highlights for Parents. Parent's Guide to Cord Blood Foundation newsletter Published 2020-07
  • Cartilage Tear: Statistics on occurrence from Louw QA, Manilall J, Grimmer KA. Epidemiology of knee injuries among adolescents: a systematic review. Brit. J Sports Med 2008;42(1)2-10. doi:10.1136/bjsm.2007.035360
  • Cartilage Tear CARTISTEM® product for treatment of repetitive and/or traumatic cartilage degeneration including degenerative osteoarthritis(OA) without age limit
  • Cerebral Palsy: Statistic 2 per 1000 full term births is incidence rate from Centers for Disease Control (CDC)
  • Cerebral Palsy: Statistic 2.2% of premature births from van Haastert IC et al. Pediatrics 2011; 159(1):86-91 doi:10.1016/j.jpeds.2010.12.053
  • Cerebral Palsy: Statistic 1 in 300 children ages 5-10 is prevalence from CDC.
  • Cerebral Palsy review of all cell therapy trials:  Paton MCB, Finch‐Edmondson M, Fahey MC, London J, Badawi N, Novak I. Fifteen years of human research using stem cells for cerebral palsy: A review of the research landscape. J Paediatrics Child Health 2021; 57:295-296. doi.org/10.1111/jpc.15329
  • Cerebral Palsy review of allogeneic cord blood trials: Paton MCB, Wall DA, Elwood N, Chiang KY, Cowie G, Novak I, Finch-Edmondson M. Safety of allogeneic umbilical cord blood infusions for the treatment of neurological conditions: a systematic review of clinical studies. Cytotherapy 2021; 8 pages. doi.org/10.1016/j.jcyt.2021.07.001
  • Expanded Access Program clinical trial NCT03327467 offers cord blood therapy (both autologous and sibling) to children with brain injuries including: autism spectrum disorder (ASD), cerebral palsy (CP), traumatic brain injury, and others. Apply here.
  • Heart defects, congenital requiring surgery, statistics: Botto LD, Correa A, Erickson JD.  Racial and temporal variations in the prevalence of heart defects. Pediatrics 2001; 107(3):E32. doi:10.1542/peds.107.3.e32
  • Heart defect surgery with autologous cord blood: Chasovskyi, K., Fedevych, O., Vorobiova, G., Zhovnir, V., Maksimenko, A., Boychenko, O., Lysak, Y., Cohen, G. and Yemets, I., 2012. Arterial switch operation in the first hours of life using autologous umbilical cord blood. Annals Thoracic Surgery 2012; 93(5):1571-1576. doi:10.1016/j.athoracsur.2012.01.104
  • Hydrocephalus publication autologous cord blood therapy: Sun JM, Grant GA, McLaughlin C, Allison J, Fitzgerald A, Waters-Pick B, Kurtzberg J. Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus. Nature Pediatric Research 2015; 78:712–716.
  • Hypoxic Ischemic Encephalopathy (HIE): Statistics 2 per 1000 are from Smith, J. etal. BJOG 2000;107(4):461-6 doi: 10.1111/j.1471-0528.2000.tb13262.x
  • Hypoxic Ischemic Encephalopathy (HIE) publication autologous cord blood therapy: Liao Y,  Cotten M, Tan S, Kurtzberg J, Cairo MS. Rescuing the neonatal brain from hypoxic injury with autologous cord blood. Nature BMT 2013; 48:890–900.
  • Hypoxic Ischemic Encephalopathy (HIE) publication autologous cord blood therapy: Cotten CM, Murtha AP, Goldberg RN, ... Rattray B, Tan S, Kurtzberg J. Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy. J Pediatrics 2014; 164(5):973-979. doi.org/10.1016/j.jpeds.2013.11.036
  • Lifetime Probability of Stem Cell Transplant in USA: Nietfeld JJ, Pasquini MC, Logan, BR, Verter, F, Horowitz MM. Lifetime Probabilities of Hematopoietic Stem Cell Transplantation in the U.S. BBMT 2008; 14(3)316–322. doi:10.1016/j.bbmt.2007.12.493
  • Premature Lungs: Statistics BronchoPulmonary Dysplasia (BPD) 25% babies born weighing under 1500gm from Van Marter LJ. Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med. 2009;14(6):358-366 doi: 10.1016/j.siny.2009.08.007.
  • Premature Lungs review of novel treatments: Bonadies L, Zaramella P, Porzionato A, Perilongo G, Muraca M, Baraldi E. Present and Future of Bronchopulmonary Dysplasia. J Clin Med 2020; 9(5):1539. doi.org/10.3390/jcm9051539
  • Premature Lungs PNEUMOSTEM® product for preventive treatment of bronchopulmonary dysplasia (BPD)
  • Stoke statistics 795,000 Americans per year and 87% ischemic: Stroke Awareness Foundation
  • Stroke publication allogeneic cord blood therapy: Laskowitz DT, Bennett ER, Durham RJ, Volpi JJ, Wiese JR, Frankel M, Shpall E, Wilson JM, Troy J, Kurtzberg J. Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study. Stem Cells Translational Medicine 2018; 7(7):521-529 10.1002/sctm.18-0008
  • Stroke review of clinical trials: Verter F. Research on Allogeneic Cord Blood for Stroke. Parent's Guide to Cord Blood Foundation newsletter Published 2019-09
  • Thalassemia Statistics Worldwide: News Medical Life Sciences. Thalassemia Prevalence. Last updated 2021-05-22
  • Thalassemia Statistics India: Colah R, Italia K, Gorakshakar A. Burden of thalassemia in India: The road map for control.  Pediatric Hematology Oncology J 2017; 2(4):79-84. doi.org/10.1016/j.phoj.2017.10.002
  • Thalassemia therapy with cord blood transplant: Locatelli F, Kabbara N, Ruggeri A, ... Gluckman E, Walters MC, Rocha V & EBMT group. Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling. Blood 2013; 122(6):1072-1078. doi.org/10.1182/blood-2013-03-489112
  • Traumatic Brain Injury (TBI): Statistics on occurance from Brain Injury Assoc. of America
  • Traumatic Brain Injury (TBI) publication autologous cord blood therapy: Cox Jr CS, Baumgartner JE, Harting MT, et al. Autologous Bone Marrow Mononuclear Cell Therapy for Severe Traumatic Brain Injury in Children. Neurosurgery 2011; 68(3):588–600. doi.org/10.1227/NEU.0b013e318207734c