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Odds of use
Legend:
| BLUE boxes | standard therapies |
| PINK boxes | clinical trials |
Odds of a child using its own (autologous)
Cord Blood Stem Cells
| Odds | Indication |
| 1 in 5,000 in USA | Stem Cell Transplant by age 20 |
| #1 cause childhood death in USA: 435,000 per year ages 0-14 | Traumatic Brain Injury |
| 1 in 8 (12.5%) kids ages 6-19 in USA | Acquired Hearing Loss Prevalence |
| 1 in 59 (1.7%) kids in USA | Autism Prevalence |
| 1 in 300 (0.3%) all kids ages 5-10 in USA | Cerebral Palsy Prevalence |
| 2 per 1000 (0.2%) babies at full-term birth worldwide | Cerebral Palsy Incidence |
| 2.2 per 100 (2.2%) babies at premature birth worldwide | Cerebral Palsy Incidence |
| 1 per 3500 births | Stroke before or at birth |
| 1.7 per 1000 ages birth-19 | Type 1 Diabetes diagnosis rate |
| 0.2 per 1000 at birth | Hypoplastic Left Heart Syndrome |
Table researched by Frances Verter, PhD ©2014-2019; References Below
Odds of a child using donor (allogeneic, includes siblings) Cord Blood Stem Cells
| Odds | Indication |
| 1 in 2,500 in USA | Stem Cell Transplant by age 20 |
| 1 in 2,000 in India | Thalassemia births in all of India, up to 10% of children have Thalassemia in some castes |
| 1 in 4 (25%) premies under 1500gm | Premature Lungs (BPD) |
| 1 in 500 worldwide | Cerebral Palsy among full term births (donor stem cell therapy available in S. Korea) |
| 2.5 per 1000 people, over 80% of them diabetics | Critical Limb Ischemia |
| 1.7 per 1000 ages birth-19 | Type 1 Diabetes diagnosis rate (donor stem cell therapy available in China) |
| 1 in 10 adolescents | torn knee cartilage incidence (stem cell therapy approved in S. Korea, now in USA trials) |
Table researched by Frances Verter, PhD ©2014-2019; References Below
References
Lifetime Probability of Stem Cell Transplant in USA
Nietfeld JJ, Pasquini MC, Logan, BR, Verter, F, Horowitz MM 2008; BBMT 14(3)316–322 doi:10.1016/j.bbmt.2007.12.493
Autism
Statistic 1 in 59 children have autism spectrum disorders is prevalence from CDC. See also Autism Speaks.
Cartilage Repair
Statistics on occurance from Louw et al. Brit. J Sports Med 2008;42(1)2-10 doi:10.1136/bjsm.2007.035360
News report on Cartistem approval
Cerebral Palsy
Statistic 2 per 1000 full term births is incidence rate from Centers for Disease Control (CDC)
Statistic 2.2% of premature births from van Haastert IC et al. Pediatrics 2011; 159(1):86-91 doi:10.1016/j.jpeds.2010.12.053
Statistic 1 in 300 children ages 5-10 is prevalence from CDC.
- Sun, J et al. Transfusion Sept. 2010; 50(9):1980-1987 doi:10.1111/j.1537-2995.2010.02720.x
- Papadopoulos, K et al. Restorative Neurology and Neuroscience 2011; 29:17-22 doi:10.3233/RNN 20110572
- Purandare C et al. Case Rep. Trans. 2012; Article ID825289, 6 pages doi:10.1155/2012/825289
- Min K et al. Stem Cells 2013; 31(3):581-591 doi: 10.1002/stem.1304
- Mancías-Guerra C et al. Cytotherapy 2014; 16(6):810-820 doi:10.1016/j.jcyt.2014.01.008
- Wang X-D et al. Cytotherapy 2015; 17:224-231 doi:10.1016/j.jcyt.2014.09.010
- Feng M et al. Stem Cells Int. 2015; 2015:325652 doi:10.1155/2015/325652
Critical Limb Ischemia
Statistics on occurance from Bitar, FG & Garcia, LA Vascular Disease Management 2010;7:E182-E184
Hearing Loss (cord blood trial is for acquired sensorineural type)
Statistics on 1 per 1000 births with bilateral sensorineural hearing loss of at least 40 dB from
Smith, RJH, Bale Jr, JF, & White, KR. Lancet 2005; 365:879-90 doi:10.1016/S0140-6736(05)71047-3
Statistic: 12.5% of children ages 6-19 (5.2 million) suffer noise-induced hearing loss.
Niskar AS et al. JAMA.1998;279:1071-1075. AAP publications
Animal study: Revoltella RP, et al. Cell Transplant 2008;17(6):665-678 PMID:18819255
Hydrocephalus
Sun JM et al. 2015; Pediatric Research 2015; 78:712–716 doi:10.1038/pr.2015.161
Hypoplastic Left Heart Syndrome
Statistics 0.16-0.36 per 1000 live births from Fyler DC. Pediatrics 1980;65(2Pt2):375-461 (not on-line)
Neonatal Oxygen Deprivation
Statistics Hypoxic Ischemic Encephalopathy (HIE) 2 per 1000 are from Smith, J. etal. BJOG 2000;107(4):461-6 doi: 10.1111/j.1471-0528.2000.tb13262.x
- Cotten M. et al. 2013; Pediatrics 164(5):973–979 doi:10.1016/j.jpeds.2013.11.036
- Liao, Y, Cotten, M, Tan, S, Kurtzberg, J & MS Cairo, MS 2013; Bone Marrow Transplantation 48:890-900 doi:10.1038/bmt.2012.169
Premature Lungs
Statistics BronchoPulmonary Dysplasia (BPD) 25% babies born wieghing under 1500gm from
Van Marter LJ. Semin Fetal Neonatal Med. 2009;14(6):358-66 doi: 10.1016/j.siny.2009.08.007.
Traumatic Brain Injury
Statistics on occurence from Brain Injury Assoc. of America
Cox Jr., CS et al. Neurosurgery 2011; 68(3):588-600 doi:10.1227/NEU.0b013e318207734c
Type 1 Diabetes
Statistic 1.7 per 1000 ages birth-19 is prevalence from Centers for Disease Control (CDC)
Haller MJ, et al. Diabetes Care 2011;34(12):2567-9. PMCID: PMC3220832
Yong Zhao, et al. BioMed Central Medicine 2012; 10:3 doi:10.1186/1741-7015-10-3
Science Daily Report on diabetes reversal with the "Stem Cell Educator" containing allogeneic cord blood.