Odds of Use

Legend:

BLUE boxes standard therapies
PINK boxes clinical trials



Odds of a child using its own (autologous)
Cord Blood Stem Cells


Odds Indication
1 in 5,000 Stem Cell Transplant by age 20 in USA
1 in 8 kids ages 6-19 Acquired Hearing Loss prevalence in USA
1 in 68 kids Autism rate in USA
1 in 300 all kids ages 5-10 Cerebral Palsy Prevalence in USA
1 in 45 premature babies Cerebral Palsy Incidence worldwide
1.7 per 1000 ages birth-19 Type 1 Diabetes diagnosis rate
Table copyright Frances Verter, PhD 2014 - References Below


Odds of a child using donor (allogeneic, includes siblings)
Cord Blood Stem Cells


Odds Indication
1 in 2,500 Stem Cell Transplant by age 20 in USA
1 in 2,000 Thalassemia births in all of India,
up to 10% of children have Thalassemia in some castes
1 in 500 Cerebral Palsy among full term births
(donor stem cell therapy available in S. Korea)
1 in 4 premies under 1500gm Premature Lungs (BPD)
1.7 per 1000 ages birth-19 Type 1 Diabetes diagnosis rate
(donor stem cell therapy available in China)
1 in 10 adolescents torn knee cartilage incidence
(stem cell therapy approved in S. Korea, now in USA trials)
Table copyright Frances Verter, PhD 2014 - References Below



References

Autism
Statistic 1 in 68 children are on the spectrum of autism related disorders is prevalence from CDC.
Cartilage Repair
Statistics on occurance from Louw et al. Brit. J Sports Med 2008;42(1)2-10 doi:10.1136/bjsm.2007.035360
News report on Cartistem approval
Cerebral Palsy
Statistic 2 per 1000 full term births is incidence rate from Centers for Disease Control (CDC)
Statistic 2.2% of premature births from
van Haastert IC et al. Pediatrics 2011; 159(1):86-91 doi:10.1016/j.jpeds.2010.12.053
Statistic 1 in 300 children ages 5-10 is prevalence from CDC.
Sun, JJ et al. Transfusion Sept. 2010; 50(9):1980-1987 doi:10.1111/j.1537-2995.2010.02720.x
Papadopoulos, K et al. Restorative Neurology and Neuroscience 2011; 29:17-22 doi:10.3233/RNN 20110572
Purandare C et al. 2012; Case Rep. Trans. 2012; Article ID825289, 6 pages doi:10.1155/2012/825289
Wang L et al. 2013; Case Rep. Trans. Article ID 146347, 4 pages dx.doi.org/10.1155/2013/146347
Wang X et al. Cytotherapy 2013; 15(12):1549-62 doi:10.1016/j.jcyt.2013.06.001
Mancías-Guerra C et al. Cytotherapy 2014; 16(6):810-820 doi:10.1016/j.jcyt.2014.01.008
Critical Limb Ischemia
Statistics on occurance from Bitar, FG & Garcia, LA Vascular Disease Management 2010;7:E182-E184
Hearing Loss (cord blood trial is for acquired sensorineural type)
Statistics on 1 per 1000 births with bilateral sensorineural hearing loss of at least 40 dB from
Smith, RJH, Bale Jr, JF, & White, KR. Lancet 2005; 365:879-90 doi:10.1016/S0140-6736(05)71047-3
Statistic: 12.5% of children ages 6-19 (5.2 million) suffer noise-induced hearing loss.
Niskar AS et al. JAMA.1998;279:1071-1075. AAP publications
Animal study: Revoltella RP, et al. Cell Transplant 2008;17(6):665-678 PMID:18819255
Hypoplastic Left Heart Syndrome
Statistics 0.16-0.36 per 1000 live births from Fyler DC. Pediatrics 1980;65(2Pt2):375-461 (not on-line)
Neonatal Oxygen Deprivation
Statistics Hypoxic Ischemic Encephalopathy (HIE) 2 per 1000 are from
Smith, J. etal. BJOG 2000;107(4):461-6 doi: 10.1111/j.1471-0528.2000.tb13262.x
Liao, Y, Cotten, M, Tan, S, Kurtzberg, J & MS Cairo, MS 2013;
Bone Marrow Transplantation 48:890-900 doi:10.1038/bmt.2012.169
Premature Lungs
Statistics BronchoPulmonary Dysplasia (BPD) 25% babies born wieghing under 1500gm from
Van Marter LJ. Semin Fetal Neonatal Med. 2009;14(6):358-66 doi: 10.1016/j.siny.2009.08.007.
Stem Cell Transplant
Statistics on cumulative probability that a person In US will have some type of stem cell transplant by age 70, based on 2001-2003 national databases of diagnoses from SEER and transplants from CIBMTR.
Nietfeld, JJ et al., Biol. Blood and Marrow Trans. 2008;14:316-322 (full text)
Thalassemia
Statistic of 10,000 patients born per year among 20 million births in India from Jeevan Blood Bank BeTheCure.in
Statistics by Indian caste/ethnic group from
Mohanty D et al. 2013; J Community Genet. 4(1):33-42 PMC3537975
Traumatic Brain Injury
Statistics on occurence from Brain Injury Assoc. of America
Cox Jr., CS et al. Neurosurgery 2011; 68(3):588-600 doi: 10.1227/NEU.0b013e318207734c
Type 1 Diabetes
Statistic 1.7 per 1000 ages birth-19 is prevalence from Centers for Disease Control (CDC)
Haller MJ, et al. Diabetes Care 2011;34(12):2567-9. PMCID: PMC3220832
Yong Zhao, et al. BioMed Central Medicine 2012; 10:3 doi:10.1186/1741-7015-10-3
Science Daily Report on diabetes reversal with the "Stem Cell Educator" containing allogeneic cord blood.