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Family Bank: Salveo
Salveo Biotechnology is owned by Esperite N.V., listed at Euronext Amsterdam and Paris, an international company in regenerative and predictive medicine that owns both the Salveo and Cryo-Save groups of cord blood banks. Headquartered in Switzerland, Esperite has a footprint in over 40 countries across three continents.
Salveo South Africa is jointly owned by Esperite and JSE-listed Ecsponent Limited:
Africa remains the only continent that does not have a public cord blood bank. In Africa, private stem cell banking is the only option for parents. Salveo South Africa offers South African parents affordable access to a world-class cord blood and tissue stem cell bank that is governed by internationally validated protocols and procedures.
Labs and Locations
Salveo laboratory is located at their headquarters:
Salveo Biotechnology S.A.
Chemin des Aulx, 12
Geneva – Switzerland
Salveo has staff ready to accept telephone inquiries from multiple countries:
Switzerland: +41 848 26 26 26
Romania: +40 318 103 701
Austria: 0800 802 152
Belgium: 0800 262 72
France: 0800 900 996
Germany: 0800 183 0885
Italy: 800 788 660
Luxembourg: 800 8 0928
South Africa: +27 087 150 8390
Spain: 900 838 023
UK: 0808 189 0360
Ukraine: 0800 50 19 95
Salveo provides supplies for gravity collection into a blood bag.
The anti-coagulant used is CPD.
Salveo shipping kit has gel packs for thermal insulation and contains a temperature logger.
Shipping is included in the contract price within Switzerland, costs extra from outside.
Shipping arrangements are made by the bank.
Employees of the bank pick up the blood from selected hospitals in Switzerland.
Shipping is contracted to a courier service specialized in shipping of biological material.
Salveo uses the state of the art automated Sepax processing system from the Swiss company Biosafe. The processing kit is a single-use, closed system, to prevent contamination and ensure sterility of the sample.
- Processing involves a series of steps in a closed system, to remove excess red blood cells (RBCs) and plasma and bring each collection down to a uniform single unit volume of 20 ml. A uniform volume assures that freezing conditions are uniform for all units and greatly facilitates storage and automation.
- Upon arrival in the Processing Laboratory, cord blood units are “logged-in” to the database and weighed to determine the collected blood volume. To prevent mix-ups and labelling errors, samples are taken and labelled from only one unit at a time.
- A haemoglobin test is done on the cord blood before processing to ensure that no haemaglobinopathies are present.
- The cord blood is connected to the Sepax 2 kit, using a sterile-docking device, in preparation for its automated processing using the Sepax 2 platform.
- Before and after processing, small samples are removed to determine the total nucleated cells (TNC) and the estimated number of stem cells (CD34+)
- The Sepax 2 kit, containing the cord blood unit, is placed into the automated Sepax 2 device, which is automatically centrifuged twice. The first centrifugation stratifies the cellular components [RBCs, white blood cells (WBC) and platelets] separated from the plasma. The second spin harvests the blood components into the three different bags of the Sepax 2 sterile bag set: RBC bag, freezing bag [containing the WBCs, predominantly the mononuclear cells (MNCs)] and plasma bag.
- The freezing bag contains the 20 ml final product.
- Cold and sterile Dimethylsulfoxide (DMSO, 5% solution), a cryoprotectant, is then slowly added to the stem cells to prevent ice crystal formation that can destroy stem cells during freezing. It is also protective when the unit is eventually thawed.
Salveo stores the buffy coat that holds white cells and stem cells, plus testing portions.
Parents are provided with a certificate describing test results.
Before freezing, each cryoprotected cord blood unit is sealed in an overwrap bag that insulates and quarantines each unit individually within the freezer, preventing possible contamination from infected units, plastic surfaces and from organisms in the liquid nitrogen.
Each cord blood unit and 3 samples are frozen in the “controlled-rate freezer” module. We use a freezing rate of 1-2°C/minute, documented to maintain cell viability. A record of the freezing curve is printed and maintained in the computer memory.
Storage of cord blood units
All cord blood units are stored in cryogenic nitrogen tanks, in the vapour phase, at temperatures between -150°C and -196°C.
Licensing & Accreditation
Licensed by Federal Office of Public Health (Switzerland)
Accredited by Swissmedic, ISO 9001 and WHO GMP
Salveo guarantees their services with a client insurance policy that covers engraftment of the stem cells. In the event of a transplant or other stem cell therapy, the client family will receive a monetary amount.
Salveo offers free banking to families where an immediate relative has a diagnosis for which transplantation is standard therapy. Medical doctors are eligible for discounted services.
Initial enrollment cost 300€ for collection kit, free second kit for twins.
Total first year cost of enrollment + courier + cord blood processing is 1440 € if paid directly.
Storage for 20 years is included.
Payment plans available upon request for 1, 2, 3, or 4 years.
Salveo also provides storage of umbilical cord tissue, aka Wharton's Jelly.