Children who used their own cord blood

Below is a summary of all autologous treatments with cord blood through the end of 2009.  In medical terminology, autologous means the child received his or her own cord blood.  By the end of 2009 there were at least 211 such treatments, using cord blood from at least 18 family banks around the world. 

Copyright 2010 Frances Verter, Ph.D. - This data was researched and compiled by Frances Verter and may not be quoted or reproduced without a citation to this web page.

When a child is diagnosed with a disease which effects the blood or immune system, it is preferable to treat the child with somebody else's stem cells that do not contain any predisposition towards the disease (an allogeneic transplant, from a donor who is either related or unrelated).  Up until 2004, autologous cord blood treatments were only performed for solid tumors like Neuroblastoma, or for acquired blood diseases like acquired Aplastic Anemia.

• Type 1 Diabetes, also known as T1D or Juvenile Diabetes - This research began with a clinical trial run by Dr. Michael J. Haller at  Shands Hospital, University of Florida, in Gainesville, Florida, USA.  The preliminary results were announced by the American Diabetes Association in June 2007, and the final publication appeared as Haller MJ, et al., Nov 2009, Diabetes Care 32(11):2041-6.  Based on the results in the US, a second trial was approved in Germany.
  

• Cerebral Palsy and other newborn brain disorders - Most of the autologous cases compiled in this category between 2005 and 2009 were treated by Dr. Joanne Kurtzberg at Duke University, in Durham, North Carolina, USA.  There have been anecdotal reports of the patients' recoveries in the media (Abby , Chloe at age 2, Chloe at age 3.5, Dallas).  As of spring 2010, a formal publication is in preparation describing the first hundred or so cases. 
  

• Cerebral Palsy - Preliminary studies of safety and efficacy have begun in Asia.  Papadopoulos, Low & Aw 2009 report on the first 4 cases of Cerebral Palsy treated in Asia between 2007 and 2009, and BabyBanks of Taiwan is preparing a publication on 4 Cerebral Palsy cases treated during 2009 (Dr. Chris Tsai, private communication).

• Cerebral Palsy - A new clinical trial began Jan. 2010 in the USA at the Medical College of Georgia, led by Dr. James Carroll.  It will be a double-blind, placebo-controlled trial.  It is limited to children who stored their cord blood with the family bank Cord Blood Registry.  Many of the participants will be recruited through the Newborn Possibilities program developed at the Tucson Medical Center.
  

• Hypoxic Ischemic Encephalopathy - Currently, Duke university is running a clinical trial of autologous cord blood therapy for this condition.  The goal is to treat infants born with signs of brain injury within two weeks of birth.  At Duke's sister school, the National University Hospital in Singapore, a trial is running the same protocols under lead investigator Dr. Lee.

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• Falcon, Krauss, Gunter 2006 Abstract#45 ISCT
• Ferreira et al. 1999 Bone Marrow Transplantation 24:1041
• Fruchtman et al. 2001 Poster #2872 ASH#43
• Fruchtman et al. 2004 Biol. Blood Marrow Transplantation 10(11):741-2.
• Harris, Mapother, Brown 2003 Poster #6 ISCT
• Hayani et al. 2007 Pediatrics 119:296-300
• Hough et al. 2003 Poster  #5306 ASH#45 in Blood 102(11)
• Thornley et al. 2004 Blood 104(11)
• Husakova & Sejnova 2008 SIOP abstract
• Papadopoulos et al. 2008 23rd Royal Thai COG Abstract
• Papadopoulos, Low & Aw 2009 2nd international congress on Responsible Stem Cell Research (RSCR, Nov. 26-28, Monaco) Abstract#24
  

• BIONET/BabyBanks - private communication Chris Tsai, PhD, CEO BIONET
• CBR Transplant List
• CorCell - private communication Jack Goldberg, MD, Medical Director
• CordBank - private communication Jenni Raynish, Managing Director
• CordLife - private communication Cherie Daly, PhD, Group Manager, Medical Affairs
• Cryo-Cell Transplant List
• Elie Katz Umbilical Cord Blood Bank - private communication David E. Sharp, MD, PhD, Medical Advisor
• Eurocord-Slovakia - private communication Ass. Prof. Mikulas Hrubisko, MD, PhD, Medical Advisor
• FamilyCord (formerly Family Cord Blood Services or California Cryobank Cord Blood Bank) - private communication Charles A. Sims, MD, Medical Director
  
• Insception Biosciences (formerly Mt. Sinai Hospital, Toronto) - private communication Robert Casper MD, Medical Director
• LifebankUSA Transplant List
  
• MAZE Cord Blood Laboratories - private communication Michael A. Werner, MD, Medical Director
  
• Progenics Cord Blood Cryobank -  private communication Hongyou Yang PhD, Laboratory & Scientific Director
• THAI StemLife - private communication Kostas I. Papadopoulos, MD, PhD, Chief Operations Officer
  
• ViaCord Transplant List
• VITA 34 Transplant List

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